What is the outcome when the pitcher legally attempts a pick-off before a coach appeals for a missed base?

When a pitcher legally attempts a pick-off before a coach appeals for a missed base, the appeal is considered denied. In baseball, the timing and sequence of plays are crucial, and the rules dictate that a legal pick-off attempt interrupts the appeal process. Since the appeal must be made while the play is still live and before any significant actions like a pick-off occur, the action of the pitcher can render the appeal moot. Essentially, the game continues with the outcome of the pick-off attempt taking precedence, which means that the appeal regarding the missed base cannot be upheld after the pick-off has been attempted. This maintains the flow of the game and adheres to the protocols established in baseball rules.